Bisphenol A and Other Metabolites in Human Saliva and Urine Associated with the Placement of Composite Restorations

摘要

Dental composite resins are formulated from a mixture of monomers and are most commonly based on bisphenol A glycidyl methacrylate (bis-GMA). A study by Olea et al (1996) reported that detectable quantities of specific compounds, bisphenol A (BPA), bis-GMA and bis-DMA were present in saliva after placement of a dental sealant. They also reported that these compounds possess estrogenic properties. This raised concern regarding the safety of dental sealants and composite restorations. Although several studies have been conducted in humans using dental sealants, there are virtually no data available from human studies using dental composite restorations, This suggests the need for research investigating potential leaching and systemic absorption of dental composite constituents. This is particularly relevant in light of the data from the American Dental Association survey of dentists which documented a large increase in the number of composite restorations being placed in the past decade (ADA, 2001). In 1999 an estimated 80 million composite fillings were placed by U.S. dentists. Compounds containing the BPA moiety may have estrogenic activity. Therefore, the primary goal of this study is to determine the concentration of chemicals containing BPA in saliva and urine following placement of dental composites.