Role of Tumor Microenvironment on Prostate Cancer Progression

摘要

Current therapies for invasive and metastatic prostate cancer are not curative and prolong survival by nearly a year even in patients with a metastatic disease. Metastasis is a multi-step process wherein tumor cells acquire properties that enable them to detach, migrate, gain access to conduits, and disseminate throughout the body. The dissemination of cancer from the primary carcinoma mass requires a loosening of the cell-cell bonds. Previous investigations have demonstrated that the epidermal growth factor receptor (EGFR) promotes tumor cell invasiveness and metastasis. However, the regulatory control of metastasis genes have not explored the key molecular events mediated by the EGFR induced responses. Recently, Kaiso a biomodal transcription factor, has been shown to be associated with, many cancer-related genes which function as tumor suppressor, such as cell cycle regulator CDKN2A (P16), TIMPS and E- cadherin. However, a direct link between Kaiso and metastasis as not been shown. Therefore, we hypothesized that Kaiso fits into the EGFR signaling cascade, and is associated with EGFR induced cell migration and metastasis.