Genomic Typing of Red Cell Antigens.

摘要

Accurate typing for Blood groups is pivotal for successful transfusion. Historically serological reagents have shown to provide reliable typing for various blood groups within individual ethnic groups [1]. However, several populations have not adequately typed and gene frequencies of various blood types have not been established. Typing reagents are not universal as different ethnic groups show subtle nucleotide sequence variations accounting for the polymorphic nature of the blood types, in addition to varying in the gene distribution among populations [2 8]. To understand the serological disparities at molecular level we have undertaken side by side comparison of serological and molecular typing. This will facilitate development of various molecular methods for a rapid and accurate typing of blood groups.