The Effects of Drug-Induced Alterations of the Autonomic Nervous System on the Responses of Mammals to Oxygen Deprivation

摘要

The cardiovascular reactions of the mammal to sudden withdrawal of oxygen from the inspired atmosphere include rise of blood pressure and rise of heart rate. While reflexes activating the sympathetic division of the autonomic nervous system are involved in creating these responses, the importance of epinephrine release and of neural activation of arterial musculature in specific areas remain unassessed. With the discovery in recent years of new chemical agents which present with varying specificity abilities to block the autonomic effector paths, the possibility beckons that use of these drugs may elicit basic information about the reaction to oxygen want. Accordingly several hundred experiments were performed in anesthetized dogs and rabbits. Clarification of the mechanisms did not result but certain items of basic information gleaned have been reproduced here in the form of their scientific publication.