Acute Toxicity of Tetrahydrocannabinol to Mice in Altered Environments

摘要

A dose range study and an acute intraperitoneal toxicity study were performed with tetrahydrocannabinol. The purpose was to determine whether any differences in physiological activity or acute intraperitoneal toxicity (LD50) could be observed in mice housed at room temperatures of 70F and 40F, mice receiving tetrahydrocannabinol at a room temperature of 40F exhibited the same physiological effects as mice receiving tetrahydrocannabinol at a room temperature of 70F. The acute intraperitoneal LD50 of tetrahydrocannabinol in mice at 70F WAS APPROXIMATELY +