CARCINOGENESIS EST FAST NEUTRONS RELATIVE 10 X RAYS IN MICE: EFFECT OF UNINEPHRECTOMY AND OF CCI4

摘要

Young adult LAF1, mice received a single sublethal exposure to fission spectrum neutrons, and were treated as follows:nGroup I - 195 to 199 red followed by a single subcutaneous injection of CCL4 one month later; Group II - CCL4, injected one day prior to neutron irradiation (280 - 329 rad); Group III - CCL4 only; no irradiation; Group IV - unilateral nephrectomy carried out one day before neutron irradiation (320 - 328 rad); Group V - neutron irradiation only (200 -320 red). In the Group I mice sacrificed 12 - 16 months post irradiation, 75# exhibited hepatomas, while 92％ of the mice in Group II showed hepatomas. By contrast, liver tumors appeared in 14％ of mice receiving neutron irradiation only (Group V), and in only 2.4％ of mice exposed to a single dose (500 rad of 200 kvp X ray).