Indolylalkylamines as Radioprotectants

摘要

To determine whether a combination of derivatives causes less toxicity in achieving the radioprotective effect of tryptamine, laboratory rats were injected intraperitoneally with 5-hydroxytryptamine alone, and in combination with 5-methoxytryptamine and sodium hexobarbital, before exposure to 1,200 R gamma radiation. Results show that survival increases when the agents are given in certain combinations. Thirty-day survival (27/30) of rats treated with the triple drug combination was significantly greater than the survival of rats treated with any of the drugs individually. These data suggest that an additive or synergistic effect may be present when the agents are administered in combination. The data also suggest that radioprotection by indolylalkylamines is more effective against 1,200 R gamma delivered over a short interval than against the same dosage over a more extended interval. The optimum time for drug administration was found to be approximately 15 minutes before irradiation. To extend this radioprotection to primates, Macaca mulatta were injected intraperitoneally with the triple drug combination before exposure to 850 R x-rays. Of the treated primates, 4 out of 15 survived. (Author)