Drug and Vaccine evaluation in the Human Aotus Plasmodium falciparum Model

摘要

Next generation quinoline methanol (NGQM) lead analog 8SF5MQ (WR 319689) when administered to Aotus monkeys infected with Plasmodium falciparum FVO orally at 6.25 mg/kg cleared and recrudesce but at 2.1 mg/kg had no effect over parasitemia. In contrast, mefloquine at 6.25 mg/kg cleared and cured but at 2.1 mg/kg only suppressed. Additionally, we were able to cryopreserved Aotus blood at high density parasitemias > 50 x 1000 x microL for both Plasmodium vivax AMRU-1 and P. vivax SAL-1 parasites that will be used at WRAIR for in vitro culture experiments. In another series of experiments, WR621308 at 65 m/kg suppressed parasitemia in Aotus infected with P. falciparum FVO but toxic adverse effects observed in one animal stopped the experiment at a higher dose (130 mg/kg).