Enhancement of Drug Absorption after Administration by an Automatic Injector.

摘要

Drug absorption after administration by two self-injection devices was investigated in normal volunteer subjects. Seven subjects received atropine (2mg) by conventional needle and syringe administration,by Syrette administration,and by AtroPen administration. Twelve subjects received pralidoxime chloride (600mg) by needle and syringe and by ComboPen (a larger version of the AtroPen). Heart rate change and plasma concentration were the respective indices of absorption of atropine and pralidoxime. After AtroPen administration of atropine,the onset of tachycardia and time of maximal tachycardia occurred significantly (p<0.02) sooner than by the two other techniques. The oxime injected by the ComboPen produced a therapeutic plasma concentration in 66% of the time (3.7and 5.7minutes) needed after conventional administration. The spring-operated devices,the AntroPen and the ComboPen,are not only easy to operate,but they cause more rapid absorption of the drug. (Author)