Prostaglandins and Aspirin Therapy in Bartter's Syndrome.

摘要

a young patient with Bartter's syndrome was treated for three months with 100 mg/kg/day of aspirin to inhibit prostaglanin synthesis. Clinical symptoms resolved and serum potassium increased from 2.9 to 3.5 mEq/L. Urinary excretion and plasma concentration of prostaglandins E and F were significantly reduced during aspirin therapy. Plasma renin activity declined from 85 to 20 ng/ml/hr (normal 1.5-4 ng/ml/hr) and hyperaldosteronism was corrected. These results suggest that overproduction of prostaglandins has a central role in the pathogenesis of Bartter's syndrome. (Author)