Toxicology of Cyclotrimethylenetrinitramine (RDX): Distribution and Metabolism in the Rat and the Miniature Swine.

摘要

Cyclotrimethylenetrinitramine (RDX) is an explosive extensively used by the military. It has caused convulsions in military field personnel ingesting it and in munition workers inhaling its dust during manufacture. At least one fatality was attributed to RDX toxicity in an European munitions manufacturing plant. In this country, RDX has been dumped into open pits for disposal after demilitarization, and in some instances has contaminated surface and ground water. It is possible that humans might be exposed to RDX in potable water. This study, initiated at the request of the Naval Medical Research and Development Command, was intended to determine the distribution, metabolism and excretion of RDX in laboratory animals and to estimate by inference the potential hazard to humans from RDX exposure.