Topical Hazard Evaluation Program of Candidate Insect Repellent AI3-36401 US Department of Agriculture Proprietary Compound - AMIDE.

摘要

A preliminary hazard evaluation of AI3-36401 was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound did not produce skin irritation, cause a photochemical irritation in rabbits, did not sensitize guinea pigs and did not demonstrate an acute ingestion hazard. Technical grade AI3-36401 did, however, demonstrate a potential for causing mild injury to the cornea and some injury to the conjunctiva. It was recommended that AI3-36401 be approved for further testing as a candidate insect repellent. It should, however, be used with caution around eyes and mucosa. (Author)