Toxicology Study of Diisopropyl Methylphosphonate and Dicyclopentadiene in Mallard Ducks, Bobwhite Quail and Mink

摘要

This study was conducted to determine the toxicity, and tissue residue accumulation, of diisopropyl methylphosphonate (DIMP) and dicyclopentadiene (DCPD) in wildlife. The toxicity was evaluated by acute (LD50), subacute (LC50) and chronic tests with Mallard ducks, Bobwhite quail, and mink. Tissue residue analyses for DIMP and DCPD were conducted with Mallard ducks and Bobwhite quail. Based on the results of the LD50 tests, DIMP was only slightly toxic to the test animals. An LD50 of 1490, 1000, and 503 mg/kg of body weight was determined for the Mallard, Bobwhite, and mink, respectively. The birds fed the diets with radioactive DIMP had 14C residues averaging less than 1 ppm which declined to less than detection limits, averaging 0.04 ppm, in most tissues, by the 3rd day after withdrawal. All tissues but skin were clear of residue by day 5 off radioactive feed. Skin had 0.05-0.1 ppm at that time. In the dosing experiment, residues at the second hour were 5.1 to 756 ppm, depending upon tissue and species. The residues, however, decreased rapidly with a biological half-life of 12.7 hours. Most tissues were at, or below, detection limits in 48 hours and clear at 65 hours, based on the half-life value. DIMP was not concentrated in the adipose tissue of either the ducks or quail.