Subchronic Inhalation Toxicity of 3-(Phenoxyphenyl) Methyl (+ or -)-CIS, Trans-3-(2,2-Dichloroethenyl)-2,2-Dimethylcyclopropanecarboxylate (Permethrin) May-December 1978

摘要

The inhalation toxicity of 3-(phenoxyphenyl) methyl (+ or -)-cis, trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate (Permethrin) AI3-29158 was determined in rats, beagle dogs, and guinea pigs. They were exposed to the aerosolized test material 6 hours per day for 13 weeks at concentrations of 500, 250, and 125 mg/cu m. The aerosolized technical grade material produced tremors and convulsions in Sprague-Dawley rats at the 500 mg/cu m concentration. These toxic reactions disappeared by the second week of the study and were not observed in the other test animals. No gross or microscopic compound-related pathological changes were observed in the three species. Oxygen consumption was monitored in the rats. No differences from cage controls were found in any test group; urine metabolite studies indicated that the material is rapidly metabolized and excreted. Enzyme induction studies run in postexposure male rats indicated that the group exposed to 500 mg/cu m had induction of liver enzymes. No permanent changes were observed in dogs, rats or guinea pigs as a result of repeated exposures to aerosols of Permethrin for 6 hours per day, 5 days per week for 13 weeks at concentrations of 500, 250, and 125 mg/cu m. Ninety-day subchronic inhalation studies in three species resulted in a no effect concentration of 125 mg/cu m. (Author)