Effects of Acute Alterations in Hemodynamics Oxygen Availability and Acid-Base Balance on the Permeability of the Gastric Mucosa

摘要

Using a previously described model for acute gastric mucosal ulcerogensis, studies indicate the following: Systemic 16,16 DM PGE2 is cytoprotective in bile acid treated gastric mucosa. Such cytoprotection is dose dependent, is not a function of mucosal blood flow, and is unrelated to bicarbonate secretion. Rather the data suggest that maintenance of normal mucosal transport is responsible; De-conjugated bile acids induce significantly greater physiologic damage to proximal gastric mucosa then do conjugated bile acid, a circumstance which may be related to the greater capacity of de-conjugated bile acids to extract integral proteins from the lipid layer of cell membranes; Surface epitheleal cells probably represent the site responsible for the restrictive permeability to cations characteristic of normal proximal gastric mucosa. (aw)