Mutagenic Potential of 4-Nitrophenyl Methyl (Phenyl) Phosphinate Using the Drosophila melanogaster Sex-Linked Recessive Lethal Test

摘要

4-Nitrophenyl methly (phenyl) phosphinate (tw011) is being considered as a prophylactic agent in anticholinesterase poisoning. This compound was tested for mutagenic activity using Drosophila melanogaster Sex-Linked Recessive Lethal assay. It was found non-mutagenic after 72-hour feeding exposures to 0.002 and 0.0025 mM of tw011.