Topical Hazard Evaluation Program of US Department of Agriculture Candidate Insect Repellent AI3-20784-Gc (N,N-diethyl-d, l-mandelic Acid Amide (DEM)), November 1983 - April 1984

摘要

Chemical AI3-20784-Gc (DEM) produced mild primary irritation of the intact skin and of the skin surrounding an abrasion. It produced moderate injury to the cornea and, in addition, some injury to the conjunctiva upon application to the eyes of rabbits. Ocular injury noted was decreased by washing with water following application and was resolved in all test animals by seven days post-application. Chemical AI3-20784-Gc (DEM) did not produce sensitization or photo-chemical irritation and was relatively nontoxic upon ingestion. Recommend that chemical AI3-20784-Gc (N,N-diethyl-d, 1-mandelic acid amide (DEM)) be approved for further testing as a candidate insect repellent if its entomological efficacy is superior to currently used repellents. This chemical should be used with extreme caution around the eyes and mucosal surfaces. Should the chemical be accidently introduced into the eye, it should be flushed with copious amounts of water. (Author)