Biological Determinants of the Behavioral Effects of Acetylcholinesterase Inhibitors

摘要

This report describes the effects of atropine, atropine methylnitrate, scopolamine scopolamine methylbromide, homatropine, homatropine methylbromied and benactyzine on fixed ratio (FR) responding in rested and acutely exercised rats. In addition, these rats were retested after an 8 and 10 week treadmill exercise conditioning regimen. The beneficial effects of conditioning are discussed in terms of the protection from the exercise-induced change in drug potency and in the decrease in muscarinic antagonist potency in rested subjects that had been conditioned. The acute effects of GD on FR and DRL responding is presented. Keywords: Operant behavior, Exercise, Muscarinic antagonists, Tolerance, Soman, Rats, Exercise conditioning, Central nervous system. (KT)