Antagonism by Taurine of Pressure-Induced Tremor in the Guinea Pig

摘要

The tremorogenic effect of high pressure was antagonized in guinea pigs by intravenous treatment with taurine in doses of 250 and 500 mg/kg. Also pretreatment with 250 mg/kg taurine suppressed tremor development as evidenced by increased threshold and decreased amplitude. It is hypothesized that antagonism of pressure-induced tremor by taurine may be related to changes in membrane calcium transport. Originator supplied keywords include: pressure; high pressure nervous syndrome; calcium transport; adenosinetriphosphatase.