General Synthesis for Symmetrical Highly Branched Perfluoro Ethers: A New Class of Oxygen Carriers

摘要

Most highly branched perfluoro ethers, particularly those sterically crowded around the oxygen, are currently inaccessible synthetically by conventional synthetic techniques used in organofluorine chemistry. Such compounds are of unusual biomedical interest currently because they have been found to be good oxygen carriers and quite surprisingly not to be retained in the liver. Previously linear ethers were thought by biomedical researchers to coordinate in some manner and definitely were found to be retained in the livers of mammals. Direct fluorination technology developed in our laboratories has succeeded with the synthesis of the novel compounds: bis(perfluorisopropyl) ether, bis(perfluoroispbutyl) ether, bis(perfluoroisopentyl) ether, and bis(perfluoroneopentyl) ether. Keywords: Branched, Perfluoro ethers oxygenated, Silicones oxygen; carriers.