Effects of Insecticides on GABA-Induced Chloride Influx into Rat Brain Microsacs

摘要

The action of different insecticides known to affect binding of ligands to gamma amino-butyric acid (GABA) receptors were studied on the function of GABA receptors in rat brain as assayed by GABA-induced Chlorine 36 (-) influx into membrane microsacs. This flux was inhibited by the competitive antagonist bicuculline and the noncompetitive antagonist t-butylbicyclophosphorothionate, and the GABA effect was potentiated by the tranquilizer flunitrazepam and the depressant pentobarbital, as expected for effects on a GABA receptor. The GABA-induced Chlorine 36 (-) flux was inhibited by several cyclodienes and gamma hexachlorocyclohexane (gamma-BHC) with the following order of decreasing potency: endosulfan I > endrin > endosulfan II > heptachlor epoxide > gamma-BHC > heptachlor. Keywords: Pryethroids.