Three-Dimensional Computer Graphics Brain-Mapping Project

摘要

We assembled a core group at UCSD and the Scripps Clinic and Research Foundation, which, together with participating national advisors, could solve problems that stand in the way of engaging computer graphics and database management more effectively in the solution of neurosciences problems. We aimed at improving the interface between neuroanatomy and computer graphics systems so that the groundwork for accurate quantitative morphology will be satisfactory from the neurosciences viewpoint in proceeding to achieve whole brain reconstructions. We have succeeded in developing sound methods for preparing whole brains for sectioning and microscopic analysis, with controls for reducing brain distortions in three dimensions and for correcting the inevitable distortions that accompany slicing brain tissue at microscopic intervals, for combining structure/function data, and for beginning an analysis of whole brain tissue sections at microscopic levels of detail.