Effect of 2,3,4-Trimethylpentane on the Ultrastructure of Proximal Tubular Cells in Primary Cell Culture.

摘要

To aid in the assessment of the risk of Air Force personnel working with hydrocarbon fuels and compounds, an attempt was made to further characterize the nephropathy that results from exposure to hydrocarbons. The purpose of this study was to isolate and establish purified primary cultures of male rat proximal tubular cells suitable for experimental exposure to sublethal concentrations of 2,3,4-trimethylpentane (TMP), a model hydrocarbon. Experiments were conducted to evaluated the cytotoxicity and metabolism of solubilized TMP in media containing or lacking the protein albumin.