Immune Response Gene Regulation of Immunity to Plasmodium berghei sporozoites and Circumsporozoite Protein Vaccines

摘要

We conducted a series of experiments to define Ir gene regulation of the immune response to Plasmodium berghei sporozoites and circumsporozoite (CS) protein derived subunit vaccines. The studies demonstrated that there is no apparent genetic restriction of the capacity to develop protective immunity against a large sporozoite challenge after immunization with irradiation-attenuated P. berghei sporozoites. The results support the development of full length human CS protein vaccines to take advantage of all potential T epitopes on this protein. Reprints. (kt)