Stability of Tranexamic Acid after 12-Week Storage at Temperatures from -20 deg C to 50 deg C.

摘要

Tranexamic acid (TXA) is an antifibrinolytic agent that reduces blood loss during surgery, decreases mortality in civilian and military trauma populations, was adopted for prehospital use by the British military, and is now issued to U.S. Special Operations Forces for use on the battlefield. This study tested whether storage of TXA ampoules at four temperatures (-20 degrees C, 4 degrees C, 22 degrees C, or 50 degrees C) for 1, 2, 4, and 12 weeks would result in chemical degradation and the loss of activity to block streptokinase-induced fibrinolysis in human plasma. Except for the finding that TXA ampoules cracked when frozen, this study indicated that the drug remains effective when stored under conditions likely to be encountered in the prehospital environment and outside the manufacturer s recommended temperature range for at least 12 weeks.