Toxicity of Carbon Monoxide-Hydrogen Cyanide Gas Mixtures: Expose Concentration,Time-to-Incapacitation, Carboxyhemoglobin, and Blood Cyanide Parameters

摘要

During aircraft interior fires, carbon monoxide (CO) and hydrogen cyanide (HCN)are produced in sufficient amounts to cause incapacitation and death. Time-to-incapacitation (ti) is a practical parameter for estimating escape time in fire environments. Exposures to CO-HCN mixtures have demonstrated that these gases have additive effects (producing shorter times to incapacitation), but the resulting concentrations of carboxyhemoglobin (COHb) and blood cyanide (CN-) at incapacitation are not well defined. These undefined relationships between COHb