Effects of Explosive Blast as Compared to Post-traumatic Stress Disorder on Brain Function and Structure.

摘要

The purpose of the present study is to better characterize and differentiate the effects of combat stress and explosive blast on the brain. To achieve this goal we have been collecting extensive data on brain structure and function using sophisticated magnetic resonance imaging (MRI) sequences and high density quantitative electroencephalography (EEG) recordings. We have also assessed the emotional health of troops via clinical interview and self-report measures. We have collected measures on 178 military personnel who were deployed as part of either Operation Iraqi Freedom or Operation Enduring Freedom. We have designed and implemented processing guidelines for imaging, EEG, and clinical data. To date we have found evidence for diffuse white matter abnormalities and reduced coordination of EEG activity in association with blast exposure. We have also developed a tool for systematic classification of head injury from blast when assessed by self-report.