Evaluation of Chemotherapeutic Agents Against Malaria; Drugs, Diet, andBiological Response Modifiers

摘要

In the primary blood schizonticidal test 1,043 compounds were evaluated and 186exhibited antimalarial activity. In the Thompson Test 41 experiments were performed to access suppressive and curative activity against drug-sensitive lines or lines resistant to chloroquine, mefloquine, halofantrine, quinine, WR238605, pyrimethamine, tetraoxane (WR163577), and WR99210. Twenty-two transdermal tests were performed with several artemisinin analogs. Dihydroartemisinin was the most active compound. Louderback's Sterilizing Medium was tested against drug-sensitive parasites and artemisinin-resistant ones. Special tests with trioxanes, beta-artemether, and trifluralin were done. Sixteen antioxidant experiments were done, which included testing wR238605 and tetraoxane (BM11681) in mice primed for oxidative stress. Mice were cured of cerebral malaria by altering the oxidative status of the hosts RBC's. Surviving mice were rechallenged to evaluate the curative activity of drugs.