Genomic Basis of Prostate Cancer Health Disparity Among African- American Men.

摘要

The hypothesis for this study is that copy number alteration (amplification and deletion) in a limited repertoire of genes Is highly predictive of prostate cancer metastasis. This signature is present in primary prostate cancers at the time of diagnosis and is enriched in the primary prostate cancers of African-American men, thus accounting for the health disparity of prostate cancer metastasis among them. The biological effect of these copy number events is to convey an escape from anoikis, as well as the other features that occur with metastasis. The current study will confirm this signature in prostate cancers that have been shown to metastasize , compared to those that have not and to determine the prevalence of this high-risk signature in the prostate cancers of African-American men matched for stage compared to those of European-American men. This study will also demonstrate that the signature can be detected in prostate cancer biopsies and correlated between the biopsy and associated tumor specimens. This study will answer an important question about the apparent health disparity of prostate cancer metastasis as well as develop a clinically useful tool that could be used to select treatment for men diagnosed with prostate cancer.