Amino Acid Sequence of a New Type of Toxic Phospholipase A sub 2 from the Venomof the Australian Tiger Snake

摘要

Venom from the common tiger snake, Notechis scutatus seutatus, contains severaltoxic acidic proteins which promote hypotension and hemorrhage in mice. One of these toxins, HTe, has a phospholipase A2 (PLA2) amino acid sequence. It contains 125 amino acids rather than the 119/120 found in other N. s. seutatus PLA2s, because it also has the loop of residues (62-66) found in helix D of pancreatic