Basic protein phospholipase A2 of an Elapide snake venom, amino acid sequence thereof, derivatives and fragments thereof, process for obtaining them, therapeutic compositions and diagnostic agents containing them

摘要

Basic protein isolated from venom of a snake of the family Elapidae, in particular from a Naja snake and more especially from Naja nigricollis and/or Naja mossambica pallida, designated phospholipase A2 (PLA2), fragments and derivatives of this protein, processes for obtaining them and pharmaceutical compositions which are usable in human and/or veterinary medicine, as well as diagnostic agents containing the abovementioned protein and/or its derivatives and/or its fragments. …??The abovementioned protein comprises 118 amino acids, its molecular weight is of the order of 13,300 daltons and its isoelectric point is of the order of 8.6. …??The derivatives of the abovementioned protein are modified at one of the histidines by binding an alkyl group of formula R-CH2-X. …??Use in the detection of tumour cells.