Evaluation of the Direct Actions of HI-6 in Reversing Soman-induced Tetanic Fade

摘要

The most widely accepted mechanism for the acute toxicity of organophosphorusanticholinesterase agents is irreversible inhibition of acetyicholinesterase (AChE), an enzyme present at all known cholinergic synapses (Taylor, 1990). Inhibition of AChE results in accumulation of acetyicholine (ACh), which then leads to aberrant cholinergic transmission (Katz and Miledi, 1973). The precise nature of the abnormality varies with the synapse, and can include depolorization, desensitization, repetitive firing or sustained activation (Hobbiger, 1976; Adler et al., 1992).