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Genes Development

【机译】：基因发展

ISSN：-
出版周期：Semimonthly
语言：English

起始发布年份：1987
出版者：[Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory in association with
出版地：United States

NLM刊名缩写：Genes Dev

数据库引入：PubMed: v1n1, 1987-, PMC

MeSH词表主题词：Cytogenetics*; Gene Expression Regulation*; Viruses/genetics*

备注：Title from cover. Also issued online.展开▼

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1.Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae

机译：酿酒酵母中核修饰过的引发剂tRNAMet的核监视和降解
- 作者：Sujatha Kadaba;Anna Krueger;Tamyra Trice;Annette M. Krecic;Alan G. Hinnebusch;James Anderson
- 期刊名称：《Genes Development》 | 2004年第11期
- Transfer RNA exosome RNA processing RNA turnover tRNA modification;
2.Computational definition of sequence motifs governing constitutive exon splicing

机译：控制本构外显子剪接的序列基序的计算定义
- 作者：Xiang H-F. Zhang;Lawrence A. Chasin
- 期刊名称：《Genes Development》 | 2004年第11期
- splicing pre-mRNA motifs exon enhancers silencers;
3.A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

机译：在组成型异染色质上诱导H3-K9和H4-K20三甲基化的沉默途径
- 作者：Gunnar Schotta;Monika Lachner;Kavitha Sarma;Anja Ebert;Roopsha Sengupta;Gunter Reuter;Danny Reinberg;Thomas Jenuwein
- 期刊名称：《Genes Development》 | 2004年第11期
- Histone code histone H4 Lys 20 mono- di- trimethylation Suv4-20h HMTases heterochromatin combinatorial histone methyl marks;
4.The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

机译：高等真核生物的全基因组染色质分析揭示了活性基因的组蛋白修饰模式
- 作者：Dirk Schübeler;David M. MacAlpine;David Scalzo;Christiane Wirbelauer;Charles Kooperberg;Fred van Leeuwen;Daniel E. Gottschling;Laura P. ONeill;Bryan M. Turner;Jeffrey Delrow;Stephen P. Bell;Mark Groudine
- 期刊名称：《Genes Development》 | 2004年第11期
- Epigenetics chromatin histone Drosophila chromatin immunoprecipitation microarray;
5.Alkylating DNA damage stimulates a regulated form of necrotic cell death

机译：烷基化的DNA损伤刺激了坏死细胞死亡的调控形式
- 作者：Wei-Xing Zong;Dara Ditsworth;Daniel E. Bauer;Zhao-Qi Wang;Craig B. Thompson
- 期刊名称：《Genes Development》 | 2004年第11期
- Alkylating DNA damage necrosis PARP metabolism Bax Bak p53;
6.Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability

机译：Rad54和DNA连接酶IV共同维持哺乳动物染色单体的稳定性
- 作者：Kevin D. Mills;David O. Ferguson;Jeroen Essers;Mark Eckersdorff;Roland Kanaar;Frederick W. Alt
- 期刊名称：《Genes Development》 | 2004年第11期
- DNA break repair nonhomologous end joining homologous recombination Lig4 Rad54;
7.Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

机译：同源重组和非同源末端连接因子对小鼠和细胞存活和完整性的协作
- 作者：Chrystelle Couëdel;Kevin D. Mills;Barchi Marco;Lingbo Shen;Adam Olshen;Roger D. Johnson;André Nussenzweig;Jeroen Essers;Roland Kanaar;Gloria C. Li;Frederick W. Alt;Maria Jasin
- 期刊名称：《Genes Development》 | 2004年第11期
- DNA double-strand break homologous recombination nonhomologous end-joining Ku80 Rad54;
8.SV40 T antigen interacts with Nbs1 to disrupt DNA replication control

机译：SV40 T抗原与Nbs1相互作用以破坏DNA复制控制
- 作者：Xiaohua Wu;Dror Avni;Takuya Chiba;Feng Yan;Qiping Zhao;Yafang Lin;Henry Heng;David Livingston
- 期刊名称：《Genes Development》 | 2004年第11期
- Nbs1 SV40 T SV40 origin DNA replication endoreduplication mammalian cells;
9.Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

机译：激活的致癌基因促进并与染色体不稳定性协同促进肿瘤转化
- 作者：Richard A. Woo;Randy Y.C. Poon
- 期刊名称：《Genes Development》 | 2004年第11期
- Chromosomal instability oncogenic Ras p53 transformation;
10.Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase

机译：低剂量SN1型甲基化剂诱导的失配修复依赖性G2检查点需要ATR激酶
- 作者：Lovorka Stojic;Nina Mojas;Petr Cejka;Massimiliano di Pietro;Stefano Ferrari;Giancarlo Marra;Josef Jiricny
- 期刊名称：《Genes Development》 | 2004年第11期
- ATM/ATR cell cycle arrest DNA damage signaling G2 check point methylating agents mismatch repair;
11.Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation

机译：视黄酸下游的信号传导层次可独立调节血管重塑和内皮细胞增殖
- 作者：Brenda L. Bohnsack;Lihua Lai;Pascal Dolle;Karen K. Hirschi
- 期刊名称：《Genes Development》 | 2004年第11期
- Vascular development mouse retinoic acid TGF-β fibronectin;
12.Molecular cross-talk among chromosome fragility syndromes

机译：染色体脆性综合征之间的分子串扰
- 作者：Jordi Surrallés;Stephen P. Jackson;Maria Jasin;Michael B. Kastan;Stephen C. West;Hans Joenje
- 期刊名称：《Genes Development》 | 2004年第12期
13.Loss of Apc in vivo immediately perturbs Wnt signaling differentiation and migration

机译：体内Apc的丧失立即干扰Wnt信号传导分化和迁移
- 作者：Owen J. Sansom;Karen R. Reed;Anthony J. Hayes;Heather Ireland;Hannah Brinkmann;Ian P. Newton;Eduard Batlle;Patricia Simon-Assmann;Hans Clevers;Inke S. Nathke;Alan R. Clarke;Douglas J. Winton
- 期刊名称：《Genes Development》 | 2004年第12期
- Apc Wnt signaling intestine conditional apoptosis;
14.The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex

机译：酵母端粒上正确的本构G尾的生成取决于MRX复合物
- 作者：Michel Larrivée;Catherine LeBel;Raymund J. Wellinger
- 期刊名称：《Genes Development》 | 2004年第12期
- Telomeres G-tails MRX complex yeast;
15.The loss of circadian PAR bZip transcription factors results in epilepsy

机译：昼夜节律PAR bZip转录因子的缺失导致癫痫
- 作者：Frédéric Gachon;Philippe Fonjallaz;Francesca Damiola;Pascal Gos;Tohru Kodama;Jozsef Zakany;Denis Duboule;Brice Petit;Mehdi Tafti;Ueli Schibler
- 期刊名称：《Genes Development》 | 2004年第12期
- PAR bZip proteins circadian transcription factors epilepsy pyridoxal kinase;
16.Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

机译：正常细胞周期动力学需要用E2F3抑制Arf肿瘤抑制因子
- 作者：Aaron Aslanian;Phillip J. Iaquinta;Raluca Verona;Jacqueline A. Lees
- 期刊名称：《Genes Development》 | 2004年第12期
- Tumor surveillance p19supArf/sup–p53 oncogenic activation proliferation E2F3;
17.Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway

机译：SMC1的磷酸化是ATM–NBS1–BRCA1途径中的关键下游事件
- 作者：Risa Kitagawa;Christopher J. Bakkenist;Peter J. McKinnon;Michael B. Kastan
- 期刊名称：《Genes Development》 | 2004年第12期
- ATM NBS1 SMC1 BRCA1 DNA damage;
18.Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae

机译：主轴检查点调节啤酒酵母中Cdc20p的稳定性
- 作者：Jing Pan;Rey-Huei Chen
- 期刊名称：《Genes Development》 | 2004年第12期
- Spindle checkpoint Cdc20p Mad2p kinetochore protein stability;
19.A new yeast PUF family protein Puf6p represses ASH1 mRNA translation and is required for its localization

机译：一种新的酵母PUF家族蛋白Puf6p抑制ASH1 mRNA的翻译这是其定位所必需的
- 作者：Wei Gu;Yingfeng Deng;Daniel Zenklusen;Robert H. Singer
- 期刊名称：《Genes Development》 | 2004年第12期
- ASH1 RNA localization translational regulation PUF6;
20.Hsp70 promotes TNF-mediated apoptosis by binding IKKγ and impairing NF-κB survival signaling

机译：Hsp70通过结合IKKγ并破坏NF-κB存活信号来促进TNF介导的细胞凋亡
- 作者：Ruiqiong Ran;Aigang Lu;Lu Zhang;Yang Tang;Hongyan Zhu;Huichun Xu;Yuxin Feng;Chun Han;Guoping Zhou;Alan C. Rigby;Frank R. Sharp
- 期刊名称：《Genes Development》 | 2004年第12期
- Hsp70 NF-κB IKKγ TNF apoptosis death receptor signaling;
21.In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis

机译：BMP和MAPK信号通路的体内收敛：差异Smad1磷酸化对发育和体内稳态的影响
- 作者：Josée Aubin;Alice Davy;Philippe Soriano
- 期刊名称：《Genes Development》 | 2004年第12期
- Smad TGFβ MAPK signaling germ line homeostasis;
22.Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

机译：调节区域之间需要多次相互作用才能稳定活性染色质中心
- 作者：George P. Patrinos;Mariken de Krom;Ernie de Boer;An Langeveld;A.M. Ali Imam;John Strouboulis;Wouter de Laat;Frank G. Grosveld
- 期刊名称：《Genes Development》 | 2004年第12期
- Human β-globin locus LCR ACH promoter transcription chromatin structure;
23.RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex

机译：RhoBTB2是哺乳动物Cul3泛素连接酶复合物的底物
- 作者：Andrew Wilkins;Qinggong Ping;Christopher L. Carpenter
- 期刊名称：《Genes Development》 | 2004年第8期
- Rho DBC2 cullin ubiquitin cancer;
24.p27Kip1 modulates cell migration through the regulation of RhoA activation

机译：p27Kip1通过调节RhoA激活来调节细胞迁移
- 作者：Arnaud Besson;Mark Gurian-West;Anja Schmidt;Alan Hall;James M. Roberts
- 期刊名称：《Genes Development》 | 2004年第8期
- p27supKip1/sup Rho migration actin stress fibers Ras ROCK;
25.Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo

机译：果蝇早期胚胎的有丝分裂过程中核蛋白组蛋白激酶-1使H2A Thr 119磷酸化。
- 作者：Hitoshi Aihara;Takeya Nakagawa;Kiyoshi Yasui;Tsutomu Ohta;Susumu Hirose;Naoshi Dhomae;Koji Takio;Mayumi Kaneko;Yukio Takeshima;Masami Muramatsu;Takashi Ito
- 期刊名称：《Genes Development》 | 2004年第8期
- Nucleosome phosphorylation histone code transcription NHK-1;
26.Conversion of myoblasts to physiologically active neuronal phenotype

机译：成肌细胞转化为生理活性神经元表型
- 作者：Yumi Watanabe;Sei Kameoka;Vidya Gopalakrishnan;Kenneth D. Aldape;Zhizhong Z. Pan;Frederick F. Lang;Sadhan Majumder
- 期刊名称：《Genes Development》 | 2004年第8期
- REST/NRSF REST-VP16 myoblasts neuronal differentiation muscle differentiation stem cells;
27.The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

机译：Notch目标基因Hey1和Hey2是胚胎血管发育所必需的
- 作者：Andreas Fischer;Nina Schumacher;Manfred Maier;Michael Sendtner;Manfred Gessler
- 期刊名称：《Genes Development》 | 2004年第8期
- Notch pathway angiogenesis vasculogenesis arteriogenesis Hey1 Hey2;
28.RISC is a 5′ phosphomonoester-producing RNA endonuclease

机译：RISC是一种产生5磷酸单酯的RNA核酸内切酶
- 作者：Javier Martinez;Thomas Tuschl
- 期刊名称：《Genes Development》 | 2004年第9期
- RNAi endonuclease 2′ modification;
29.Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity

机译：肝肿瘤通过PI3K / Akt介导的C /EBPα生长抑制活性的逃避增殖的负控制
- 作者：Guo-Li Wang;Polina Iakova;Margie Wilde;Samir Awad;Nikolai A. Timchenko
- 期刊名称：《Genes Development》 | 2004年第8期
- Hepatoma C/EBPα cell proliferation Akt insulin;
30.Interaction of the S-phase cyclin Clb5 with an RXL docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch

机译：S期细胞周期蛋白Clb5与启动子蛋白Orc6中的RXL对接序列的相互作用提供了原点定位的复制控制开关
- 作者：Gwendolyn M. Wilmes;Vincent Archambault;Richard J. Austin;Matthew D. Jacobson;Stephen P. Bell;Frederick R. Cross
- 期刊名称：《Genes Development》 | 2004年第9期
- Cell cycle control DNA replication cyclin-dependent kinase origin recognition complex genomic stability re-replication;
31.Ehd1 a B-type response regulator in rice confers short-day promotion of flowering and controls FT-like gene expression independently of Hd1

机译：Ehd1是水稻中的一种B型响应调节剂可在短时间内促进开花并独立于Hd1控制FT样基因表达
- 作者：Kazuyuki Doi;Takeshi Izawa;Takuichi Fuse;Utako Yamanouchi;Takahiko Kubo;Zenpei Shimatani;Masahiro Yano;Atsushi Yoshimura
- 期刊名称：《Genes Development》 | 2004年第8期
- Photoperiodism flowering time two-component signaling;
32.Pol12 the B subunit of DNA polymerase α functions in both telomere capping and length regulation

机译：Pol12是DNA聚合酶α的B亚基在端粒封端和长度调节中均起作用
- 作者：Simona Grossi;Andrea Puglisi;Petr V. Dmitriev;Massimo Lopes;David Shore
- 期刊名称：《Genes Development》 | 2004年第9期
- Telomere capping telomere length regulation DNA polymerase α DNA replication Pol12 Stn1;
33.Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

机译：神经c细胞中的刺猬信号调节面部原基的模式和生长
- 作者：Juhee Jeong;Junhao Mao;Toyoaki Tenzen;Andreas H. Kottmann;Andrew P. McMahon
- 期刊名称：《Genes Development》 | 2004年第8期
- Craniofacial development Shh Fox genes branchial arch neural crest mouse;
34.Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity

机译：NIMA激酶的募集表明粟酒裂殖酵母纺锤体的成熟在连续的细胞周期中发生并揭示了NIMA在调节SIN活性中的作用
- 作者：Agnes Grallert;Andrea Krapp;Steve Bagley;Viesturs Simanis;Iain M. Hagan
- 期刊名称：《Genes Development》 | 2004年第9期
- S. pombe NIMA kinase Fin1 mitosis SIN centrosome SPB;
35.Positive and negative functions of the SAGA complex mediated through interaction of Spt8 with TBP and the N-terminal domain of TFIIA

机译：Spt8与TBP和TFIIA N末端结构域相互作用介导的SAGA复合物的正负功能
- 作者：Linda Warfield;Jeffrey A. Ranish;Steven Hahn
- 期刊名称：《Genes Development》 | 2004年第9期
- Transcription SAGA TFIIA coactivator repression;
36.Runx2 and Runx3 are essential for chondrocyte maturation and Runx2 regulates limb growth through induction of Indian hedgehog

机译：Runx2和Runx3对于软骨细胞的成熟必不可少Runx2通过诱导印度刺猬来调节肢体生长
- 作者：Carolina A. Yoshida;Hiromitsu Yamamoto;Takashi Fujita;Tatsuya Furuichi;Kosei Ito;Ken-ichi Inoue;Kei Yamana;Akira Zanma;Kenji Takada;Yoshiaki Ito;Toshihisa Komori
- 期刊名称：《Genes Development》 | 2004年第8期
- Runx2 Runx3 chondrocyte proliferation chondrocyte maturation Ihh;
37.Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene PASG

机译：SNF2样基因PASG的破坏在小鼠中的生长发育迟缓和衰老的表型。
- 作者：Lin-Quan Sun;David W. Lee;Quangeng Zhang;Weihong Xiao;Eric H. Raabe;Alan Meeker;Dengshun Miao;David L. Huso;Robert J. Arceci
- 期刊名称：《Genes Development》 | 2004年第9期
- PASG lsh SMARCA6 methylation genomic instability aging senescence;
38.Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans

机译：GLD-1的翻译抑制可保护其mRNA靶标免受秀丽隐杆线虫的无意义介导的mRNA降解
- 作者：Min-Ho Lee;Tim Schedl
- 期刊名称：《Genes Development》 | 2004年第9期
- Germ line translation repression upstream open reading frame nonsense-mediated mRNA decay gld-1 gna-2;
39.Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

机译：血管生成素-1通过转录因子FKHR（FOXO1）调节内皮细胞功能和基因表达
- 作者：Christopher Daly;Vivian Wong;Elena Burova;Yi Wei;Stephanie Zabski;Jennifer Griffiths;Ka-Man Lai;Hsin Chieh Lin;Ella Ioffe;George D. Yancopoulos;John S. Rudge
- 期刊名称：《Genes Development》 | 2004年第9期
- Ang-1 FKHR Akt endothelial cell;
40.Interactions between Sox9 and β-catenin control chondrocyte differentiation

机译：Sox9与β-catenin之间的相互作用控制软骨细胞分化
- 作者：Haruhiko Akiyama;Jon P. Lyons;Yuko Mori-Akiyama;Xiaohong Yang;Ren Zhang;Zhaoping Zhang;Jian Min Deng;Makoto M. Taketo;Takashi Nakamura;Richard R. Behringer;Pierre D. McCrea;Benoit de Crombrugghe
- 期刊名称：《Genes Development》 | 2004年第9期
- Chondrocyte differentiation Sox9 β-catenin;
41.Divergent functions of murine Pax3 and Pax7 in limb muscle development

机译：小鼠Pax3和Pax7在四肢肌肉发育中的不同功能
- 作者：Frédéric Relaix;Didier Rocancourt;Ahmed Mansouri;Margaret Buckingham
- 期刊名称：《Genes Development》 | 2004年第9期
- Pax3 Pax7 myogenesis appendicular muscle evolution neural tube;
42.Photoreceptor ubiquitination by COP1 E3 ligase desensitizes phytochrome A signaling

机译：COP1 E3连接酶的光受体泛素化使植物色素A信号转脱敏
- 作者：Hak Soo Seo;Etsuko Watanabe;Satoru Tokutomi;Akira Nagatani;Nam-Hai Chua
- 期刊名称：《Genes Development》 | 2004年第6期
- Photoreceptor desensitization COP1 phytochrome A signaling;
43.Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification

机译：通过表亲-表兄弟细胞类型的重新指定将果蝇哈姆雷特突变体的外部感觉器官中的神经元和神经胶质转化为外部细胞命运
- 作者：Adrian W. Moore;Fabrice Roegiers;Lily Y. Jan;Yuh-Nung Jan
- 期刊名称：《Genes Development》 | 2004年第6期
- Cell fate respecification cell lineage Drosophila external sensory organ hamlet;
44.Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers

机译：人类癌症的小鼠发育视角揭示了发育和肿瘤发生过程中的保守机制
- 作者：Alvin T. Kho;Qing Zhao;Zhaohui Cai;Atul J. Butte;John Y.H. Kim;Scott L. Pomeroy;David H. Rowitch;Isaac S. Kohane
- 期刊名称：《Genes Development》 | 2004年第6期
- cerebellar development medulloblastoma comparative genomics multiscale models metastasis principle component analysis;
45.Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

机译：棕榈酸化是脊椎动物中产生可溶性多聚刺猬蛋白复合物和远程信号转导所必需的
- 作者：Miao-Hsueh Chen;Ya-Jun Li;Takatoshi Kawakami;Shan-Mei Xu;Pao-Tien Chuang
- 期刊名称：《Genes Development》 | 2004年第6期
- Cholesterol palmitoylation Hedgehog lipid modification signaling multimerization;
46.Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells

机译：Mnk-1对eIF4E的磷酸化增强了静止细胞中HSV-1的翻译和复制
- 作者：Derek Walsh;Ian Mohr
- 期刊名称：《Genes Development》 | 2004年第6期
- eIF4E phosphorylation translation HSV-1 replication 4E-BP1 degradation;
47.TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis a novel pRb-independent and E2F1-specific control for cell survival

机译：TopBP1募集Brg1 / Brm来抑制E2F1诱导的凋亡这是一种新型的pRb独立和E2F1特异性控制细胞存活的方法
- 作者：Kang Liu;Yuhong Luo;Fang-Tsyr Lin;Weei-Chin Lin
- 期刊名称：《Genes Development》 | 2004年第6期
- E2F1 TopBP1 apoptosis Brg1 Brm BRCT;
48.pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos

机译：pyramus和thisbe：FGF模式的果蝇胚胎中胚层模式
- 作者：Angelike Stathopoulos;Bergin Tam;Matthew Ronshaugen;Manfred Frasch;Michael Levine
- 期刊名称：《Genes Development》 | 2004年第6期
- FGF heartless receptor dorsal Drosophila embryo pyramus thisbe;
49.Natural genetic variation in Arabidopsis identifies BREVIS RADIX a novel regulator of cell proliferation and elongation in the root

机译：拟南芥中的自然遗传变异确定了BREVIS RADIX这是一种根部细胞增殖和伸长的新型调节剂
- 作者：Céline F. Mouchel;Georgette C. Briggs;Christian S. Hardtke
- 期刊名称：《Genes Development》 | 2004年第6期
- Arabidopsis BRX root growth root meristem natural variation gene family;
50.Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain

机译：具有新型双鸟苷酸环化酶输出域的细菌应答调节剂的细胞周期依赖性动态定位
- 作者：Ralf Paul;Stefan Weiser;Nicholas C. Amiot;Carmen Chan;Tilman Schirmer;Bernd Giese;Urs Jenal
- 期刊名称：《Genes Development》 | 2004年第6期
- Caulobacter development GGDEF domain protein localization response regulator;
51.Holoenzyme proteins required for the physiological assembly and activity of telomerase

机译：端粒酶的生理组装和活性所需的全酶蛋白
- 作者：Keren L. Witkin;Kathleen Collins
- 期刊名称：《Genes Development》 | 2004年第10期
- Tetrahymena telomerase telomere ribonucleoprotein;
52.Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription

机译：转录诱导后HoxB基因座的染色质解聚和核重组
- 作者：Séverine Chambeyron;Wendy A. Bickmore
- 期刊名称：《Genes Development》 | 2004年第10期
- Chromatin decondensation chromosome territory differentiation gene expression histone modification nuclear structure;
53.Snail blocks the cell cycle and confers resistance to cell death

机译：蜗牛阻止细胞周期并赋予对细胞死亡的抵抗力
- 作者：Sonia Vega;Aixa V. Morales;Oscar H. Ocaña;Francisco Valdés;Isabel Fabregat;M. Angela Nieto
- 期刊名称：《Genes Development》 | 2004年第10期
- Snail cell cycle cell death malignization chick embryo mouse embryo;
54.Collaboration of Brca1 and Chk2 in tumorigenesis

机译：Brca1和Chk2在肿瘤发生中的合作
- 作者：John Peter McPherson;Bénédicte Lemmers;Atsushi Hirao;Anne Hakem;Jacinth Abraham;Eva Migon;Elzbieta Matysiak-Zablocki;Laura Tamblyn;Otto Sanchez-Sweatman;Rama Khokha;Jeremy Squire;M. Prakash Hande;Tak W. Mak;Razqallah Hakem
- 期刊名称：《Genes Development》 | 2004年第10期
- Breast cancer T cell genomic instability apoptosis cell cycle proliferation;
55.Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1

机译：Chk1激活需要Rad9 S / TQ位点磷酸化来促进与Rad4TOPBP1的C端BRCT域缔合
- 作者：Kanji Furuya;Marius Poitelea;Liandi Guo;Thomas Caspari;Antony M. Carr
- 期刊名称：《Genes Development》 | 2004年第10期
- Checkpoint DNA replication fission yeast DNA damage ATR;
56.A combined computational-experimental approach predicts human microRNA targets

机译：组合的计算实验方法可预测人类microRNA靶标
- 作者：Marianthi Kiriakidou;Peter T. Nelson;Andrei Kouranov;Petko Fitziev;Costas Bouyioukos;Zissimos Mourelatos;Artemis Hatzigeorgiou
- 期刊名称：《Genes Development》 | 2004年第10期
- MicroRNA microRNA targets microRNP Argonaute bioinformatics RNAi;
57.Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step

机译：病毒RNA沉默抑制剂在中间步骤抑制microRNA途径
- 作者：Elisabeth J. Chapman;Alexey I. Prokhnevsky;Kodetham Gopinath;Valerian V. Dolja;James C. Carrington
- 期刊名称：《Genes Development》 | 2004年第10期
- MicroRNA RNA silencing RNAi virus-encoded suppressors RISC;
58.The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development

机译：ARGONAUTE1在miRNA途径中的作用及其通过miRNA途径的调控对于植物发育至关重要
- 作者：Hervé Vaucheret;Franck Vazquez;Patrice Crété;David P. Bartel
- 期刊名称：《Genes Development》 | 2004年第10期
- AGO1 miRNA negative feedback regulation posttranscriptional gene silencing RNAi;
59.Conservation of the global sex determination gene tra-1 in distantly related nematodes

机译：远缘线虫中全球性别决定基因tra-1的保存
- 作者：André Pires-daSilva;Ralf J. Sommer
- 期刊名称：《Genes Development》 | 2004年第10期
- Sex determination evolution P. pacificus C. elegans tra-1;
60.The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments

机译：T-box转录因子Tbx18保持了前节和后节的分隔
- 作者：Markus Bussen;Marianne Petry;Karin Schuster-Gossler;Michael Leitges;Achim Gossler;Andreas Kispert
- 期刊名称：《Genes Development》 | 2004年第10期
- Somite skeleton vertebra Uncx4.1 mesoderm;
61.Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates

机译：ClpX AAA + ATPase的加工孔在识别和结合特定蛋白质底物中的作用
- 作者：Samia M. Siddiqui;Robert T. Sauer;Tania A. Baker
- 期刊名称：《Genes Development》 | 2004年第4期
- AAA ATPase peptide binding protein unfolding protein translocation;
62.WUSCHEL induces shoot stem cell activity and developmental plasticity in the root meristem

机译：WUSCHEL诱导根分生组织的茎干细胞活性和发育可塑性
- 作者：Jean-Luc Gallois;Fabiana R. Nora;Yukiko Mizukami;Robert Sablowski
- 期刊名称：《Genes Development》 | 2004年第4期
- Arabidopsis WUSCHEL auxin LEAFY pluripotency embryogenesis;
63.Role of the TAK1-NLK-STAT3 pathway in TGF-β-mediated mesoderm induction

机译：TAK1-NLK-STAT3途径在TGF-β介导的中胚层诱导中的作用
- 作者：Bisei Ohkawara;Kyoko Shirakabe;Junko Hyodo-Miura;Ritsuko Matsuo;Naoto Ueno;Kunihiro Matsumoto;Hiroshi Shibuya
- 期刊名称：《Genes Development》 | 2004年第4期
- TAK1 NLK STAT3 TGF-β signal mesoderm induction;
64.Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA

机译：核仁蛋白PinX1p通过将其蛋白催化亚基螯合在缺乏端粒酶RNA的无活性复合物中来调节端粒酶
- 作者：Jue Lin;Elizabeth H. Blackburn
- 期刊名称：《Genes Development》 | 2004年第4期
- Telomerase regulation telomerase sequestration alternative telomerase complex PinX1–telomerase protein complex;
65.The promoter of the Chinese hamster ovary dihydrofolate reductase gene regulates the activity of the local origin and helps define its boundaries

机译：中国仓鼠卵巢二氢叶酸还原酶基因的启动子调节本地来源的活性并帮助定义其边界
- 作者：Swati Saha;Yujie Shan;Larry D. Mesner;Joyce L. Hamlin
- 期刊名称：《Genes Development》 | 2004年第4期
- DNA replication origins transcription mutagenesis;
66.Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

机译：Pax5诱导免疫球蛋白重链基因的V到DJ重排和基因座收缩
- 作者：Martin Fuxa;Jane Skok;Abdallah Souabni;Giorgia Salvagiotto;Esther Roldan;Meinrad Busslinger
- 期刊名称：《Genes Development》 | 2004年第4期
- Pax5/BSAP VH–DJH recombination immunoglobulin heavy-chain locus contraction subnuclear location T cells;
67.mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

机译：转录因子TIF-IA的mTOR依赖性激活将rRNA合成与养分利用率联系起来
- 作者：Christine Mayer;Jian Zhao;Xuejun Yuan;Ingrid Grummt
- 期刊名称：《Genes Development》 | 2004年第4期
- RNA polymerase I TIF-IA mTOR transcription phosphorylation PP2A;
68.Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor Plexin-A1 with off-track and vascular endothelial growth factor receptor type 2

机译：Sema6D通过其受体Plexin-A1与轨道外和血管内皮生长因子受体2型的区域特异性结合在心脏形态发生中起双重作用
- 作者：Toshihiko Toyofuku;Hong Zhang;Atsushi Kumanogoh;Noriko Takegahara;Fumikazu Suto;Junko Kamei;Kazuhiro Aoki;Masanori Yabuki;Masatsugu Hori;Hajime Fujisawa;Hitoshi Kikutani
- 期刊名称：《Genes Development》 | 2004年第4期
- Semaphorin Plexin cardiac development;
69.Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis

机译：具有Kelch-重复结构域的核蛋白磷酸酶调节拟南芥对油菜素类固醇的响应
- 作者：Santiago Mora-García;Grégory Vert;Yanhai Yin;Ana Caño-Delgado;Hyeonsook Cheong;Joanne Chory
- 期刊名称：《Genes Development》 | 2004年第4期
- Arabidopsis brassinosteroids protein phosphatase Kelch repeat BES1 BIN2;
70.Errata

机译：勘误
- 期刊名称：《Genes Development》 | 2004年第4期
71.Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5

机译：CSN5调控HIF-α的不同有氧和低氧机制
- 作者：Lynne Bemis;Denise A. Chan;Carla V. Finkielstein;Lin Qi;Patrick D. Sutphin;Xiaojiang Chen;Kurt Stenmark;Amato J. Giaccia;Wayne Zundel
- 期刊名称：《Genes Development》 | 2004年第7期
- Von Hippel-Lindau COP9 signalosome hypoxia inducible factor-1α;
72.The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex

机译：先锋翻译起始复合物在功能上与稳态翻译起始复合物不同但在结构上重叠
- 作者：Shang-Yi Chiu;Fabrice Lejeune;Aparna C. Ranganathan;Lynne E. Maquat
- 期刊名称：《Genes Development》 | 2004年第7期
- Pioneer translation initiation complex steady-state translation initiation complex nonsense-mediated mRNA decay;
73.A novel role for shuttling SR proteins in mRNA translation

机译：SR蛋白在mRNA翻译中的新作用
- 作者：Jeremy R. Sanford;Nicola K. Gray;Karsten Beckmann;Javier F. Cáceres
- 期刊名称：《Genes Development》 | 2004年第7期
- pre-mRNA splicing SR proteins nucleocytoplasmic shuttling ribosomes translation;
74.The NAD+-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication

机译：NAD +依赖性Sir2p组蛋白脱乙酰基酶是染色体DNA复制的负调节剂
- 作者：Donald L. Pappas Jr.;Ryan Frisch;Michael Weinreich
- 期刊名称：《Genes Development》 | 2004年第7期
- DNA replication SIR2 deacetylase;
75.BRU1 a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis

机译：BRU1拟南芥对DNA损伤的反应与表观遗传基因沉默之间的新型联系
- 作者：Shin Takeda;Zerihun Tadele;Ingo Hofmann;Aline V. Probst;Karel J. Angelis;Hidetaka Kaya;Takashi Araki;Tesfaye Mengiste;Ortrun Mittelsten Scheid;Kei-ichi Shibahara;Dierk Scheel;Jerzy Paszkowski
- 期刊名称：《Genes Development》 | 2004年第7期
- Arabidopsis thaliana DNA repair epigenetic inheritance gene silencing homologous recombination;
76.RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching

机译：RNase敏感的DNA修饰引发粟酒裂殖酵母交配型转换
- 作者：Sonya Vengrova;Jacob Z. Dalgaard
- 期刊名称：《Genes Development》 | 2004年第7期
- DNA modification imprint replication pausing mating-type switching Schizosaccharomyces pombe;
77.A Gα-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement

机译：Gα依赖性途径拮抗调节细胞定向运动的多种趋化因子反应
- 作者：Joseph A. Brzostowski;Carole A. Parent;Alan R. Kimmel
- 期刊名称：《Genes Development》 | 2004年第7期
- cAMP cGMP PI(345)P3 actin myosin Dictyostelium;
78.Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1 HIPK2 and NLK

机译：Wnt-1信号通过TAK1HIPK2和NLK诱导c-Myb蛋白的磷酸化和降解
- 作者：Chie Kanei-Ishii;Jun Ninomiya-Tsuji;Jun Tanikawa;Teruaki Nomura;Tohru Ishitani;Satoshi Kishida;Kenji Kokura;Toshihiro Kurahashi;Emi Ichikawa-Iwata;Yongsok Kim;Kunihiro Matsumoto;Shunsuke Ishii
- 期刊名称：《Genes Development》 | 2004年第7期
- Myb HIPK2 NLK TAK1 phosphorylation degradation;
79.Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

机译：Foxm1b转录因子对于肝细胞癌的发展至关重要并且受p19ARF肿瘤抑制因子的负调控
- 作者：Vladimir V. Kalinichenko;Michael L. Major;Xinhe Wang;Vladimir Petrovic;Joseph Kuechle;Helena M. Yoder;Margaret B. Dennewitz;Brian Shin;Abhishek Datta;Pradip Raychaudhuri;Robert H. Costa
- 期刊名称：《Genes Development》 | 2004年第7期
- Forkhead Box winged helix liver cancer p27Kip1 Cdc25B Foxm1;
80.Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

机译：DNA损伤诱导的ATM激活中蛋白质磷酸酶5的要求
- 作者：Ambereen Ali;Ji Zhang;Shideng Bao;Irene Liu;Diane Otterness;Nicholas M. Dean;Robert T. Abraham;Xiao-Fan Wang
- 期刊名称：《Genes Development》 | 2004年第3期
- DNA damage cell cycle checkpoint ATM protein phosphatase 5;
81.Distinct roles for PP1 and PP2A in the Neurospora circadian clock

机译：PP1和PP2A在Neurospora生物钟中的不同作用
- 作者：Yuhong Yang;Qun He;Ping Cheng;Philip Wrage;Oded Yarden;Yi Liu
- 期刊名称：《Genes Development》 | 2004年第3期
- frequency phosphorylation phosphatase PP1 PP2A;
82.Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β

机译：内质网应激通过涉及糖原合酶激酶3β的途径诱导p53胞质定位并防止p53依赖性凋亡
- 作者：LiKe Qu;Shirley Huang;Dionissios Baltzis;Ana-Maria Rivas-Estilla;Olivier Pluquet;Maria Hatzoglou;Costas Koumenis;Yoichi Taya;Akihiko Yoshimura;Antonis E. Koromilas
- 期刊名称：《Genes Development》 | 2004年第3期
- Endoplasmic reticulum stress p53 glycogen synthase kinase-3β protein phosphorylation protein localization apoptosis;
83.Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK

机译：通过将p160 myb结合蛋白募集到PGC-1α来抑制线粒体呼吸：p38 MAPK的调节
- 作者：Melina Fan;James Rhee;Julie St-Pierre;Christoph Handschin;Pere Puigserver;Jiandie Lin;Sibylle Jäeger;Hediye Erdjument-Bromage;Paul Tempst;Bruce M. Spiegelman
- 期刊名称：《Genes Development》 | 2004年第3期
- PGC-1α Mybbp1a mitochondria repressor p38 MAPK;
84.Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

机译：软骨细胞中MEK1的组成性激活导致非Stat1的软骨发育不全样侏儒症并拯救Fgfr3缺陷型小鼠表型。
- 作者：Shunichi Murakami;Gener Balmes;Sandra McKinney;Zhaoping Zhang;David Givol;Benoit de Crombrugghe
- 期刊名称：《Genes Development》 | 2004年第3期
- MEK1 MAPK FGFR3 Stat1 chondrocyte differentiation achondroplasia;
85.Modulation of mammalian life span by the short isoform of p53

机译：p53的短异构体对哺乳动物寿命的调节
- 作者：Bernhard Maier;Wendy Gluba;Brian Bernier;Terry Turner;Khalid Mohammad;Theresa Guise;Ann Sutherland;Michael Thorner;Heidi Scrable
- 期刊名称：《Genes Development》 | 2004年第3期
- daf2 GH growth retardation aging testis Akt Sir2;
86.Ovca1 regulates cell proliferation embryonic development and tumorigenesis

机译：Ovca1调节细胞增殖胚胎发育和肿瘤发生
- 作者：Chun-Ming Chen;Richard R. Behringer
- 期刊名称：《Genes Development》 | 2004年第3期
- Tumor suppressor ovarian cancer DPH2L1 Ovca2 HIC1 Miller-Dieker syndrome;
87.In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer

机译：通过荧光共振能量转移揭示转录激活子的体内靶标
- 作者：Sukesh R. Bhaumik;Tamal Raha;David P. Aiello;Michael R. Green
- 期刊名称：《Genes Development》 | 2004年第3期
- FRET SAGA Tra1 Gal4 Mediator activator target;
88.Cooperativity in long-range gene regulation by the λ CI repressor

机译：λCI阻遏物在远程基因调控中的协同作用
- 作者：Ian B. Dodd;Keith E. Shearwin;Alison J. Perkins;Tom Burr;Ann Hochschild;J. Barry Egan
- 期刊名称：《Genes Development》 | 2004年第3期
- DNA looping protein-protein interactions multimerization transcriptional control lysogeny;
89.p63 is the molecular switch for initiation of an epithelial stratification program

机译：p63是启动上皮分层程序的分子开关
- 作者：Maranke I. Koster;Soeun Kim;Alea A. Mills;Francesco J. DeMayo;Dennis R. Roop
- 期刊名称：《Genes Development》 | 2004年第2期
- p63 stratified epithelia molecular switch embryogenesis terminal differentiation proliferative potential;
90.The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR

机译：秀丽隐杆线虫microRNA let-7结合到来自lin-41 3UTR的不完美let-7互补位点
- 作者：Monica C. Vella;Eun-Young Choi;Shin-Yi Lin;Kristy Reinert;Frank J. Slack
- 期刊名称：《Genes Development》 | 2004年第2期
- stRNA microRNA heterochronic developmental timing 3′UTR;
91.Roles of Bifocal Homer and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes

机译：BifocalHomer和F-actin在将Oskar固定在果蝇卵母细胞后皮质中的作用
- 作者：Kavita Babu;Yu Cai;Sami Bahri;Xiaohang Yang;William Chia
- 期刊名称：《Genes Development》 | 2004年第2期
- Bifocal Homer Oskar F-actin anchoring;
92.A methylation-mediator complex in hormone signaling

机译：激素信号传导中的甲基化介质复合物
- 作者：Wei Xu;Helen Cho;Shilpa Kadam;Ester M. Banayo;Scott Anderson;John R. Yates III;Beverly M. Emerson;Ronald M. Evans
- 期刊名称：《Genes Development》 | 2004年第2期
- CARM1 SWI/SNF chromatin remodeling histone methyltransferase;
93.Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR

机译：过氧化物酶体增殖物激活受体-γ共激活因子1α（PGC-1α）通过激活核受体FXR调节甘油三酸酯代谢
- 作者：Yanqiao Zhang;Lawrence W. Castellani;Christopher J. Sinal;Frank J. Gonzalez;Peter A. Edwards
- 期刊名称：《Genes Development》 | 2004年第2期
- FXR PGC-1α HNF4α PPARγ triglyceride;
94.Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo

机译：Acf1赋予ACF / CHRAC独特的活性并促进体内染色质的形成而不是破坏
- 作者：Dmitry V. Fyodorov;Michael D. Blower;Gary H. Karpen;James T. Kadonaga
- 期刊名称：《Genes Development》 | 2004年第2期
- ACF ISWI CHRAC chromatin assembly position-effect variegation cell cycle;
95.Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B

机译：Rad6通过组蛋白H2B的泛素化在转录激活中起作用
- 作者：Cheng-Fu Kao;Cory Hillyer;Toyoko Tsukuda;Karl Henry;Shelley Berger;Mary Ann Osley
- 期刊名称：《Genes Development》 | 2004年第2期
- Rad6 gene activation H2B ubiquitylation;
96.A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits

机译：两个核糖体亚基的出口都需要与核糖体相关的HEAT重复蛋白
- 作者：Marlene Oeffinger;Mensur Dlakić;David Tollervey
- 期刊名称：《Genes Development》 | 2004年第2期
- Ribosome export;
97.Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

机译：剪接增强哺乳动物细胞中的翻译：外显子连接复合体的附加功能
- 作者：Ajit Nott;Hervé Le Hir;Melissa J. Moore
- 期刊名称：《Genes Development》 | 2004年第2期
- Gene expression splicing translation polysome exon junction complex;
98.A Glutamate Receptor–Interacting Protein homolog organizes muscle guidance in Drosophila

机译：谷氨酸受体相互作用蛋白同源物在果蝇中组织肌肉引导
- 作者：Laura E. Swan;Carolin Wichmann;Ulrike Prange;Andreas Schmid;Manuela Schmidt;Tobias Schwarz;Evgeni Ponimaskin;Frank Madeo;Gerd Vorbrüggen;Stephan J. Sigrist
- 期刊名称：《Genes Development》 | 2004年第2期
- dgrip muscle muscle guidance Glutamate Receptor–Interacting Protein Drosophila;
99.Vestibular defects in head-tilt mice result from mutations in Nox3 encoding an NADPH oxidase

机译：头倾斜型小鼠的前庭缺陷是由Nox3的突变导致的编码NADPH氧化酶
- 作者：Rainer Paffenholz;Rebecca A. Bergstrom;Francesca Pasutto;Philipp Wabnitz;Robert J. Munroe;Wolfgang Jagla;Ulrich Heinzmann;Andreas Marquardt;Armin Bareiss;Jürgen Laufs;Andreas Russ;Gabriele Stumm;John C. Schimenti;David E. Bergstrom
- 期刊名称：《Genes Development》 | 2004年第5期
- Mouse vestibular system otoconia NADPH oxidase saccule utricle;
100.Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth

机译：肝细胞糖皮质激素受体功能对促进出生后身体生长至关重要
- 作者：François Tronche;Christian Opherk;Richard Moriggl;Christoph Kellendonk;Andreas Reimann;Lukas Schwake;Holger M. Reichardt;Katharina Stangl;Daniel Gau;Andreas Hoeflich;Hartmut Beug;Wolfgang Schmid;Günther Schütz
- 期刊名称：《Genes Development》 | 2004年第5期
- Postnatal body growth glucocorticoid receptor growth hormone signaling Stat5;