The Behaviours of Connective Tissue and Blood Vessels by the Lokal Antigen Antibody Reaction

摘要

The changes of the blood vessels and connective tissue following the local antigen-antidody reaction were experimentally investigated under various conditons.The local antigen-antiboby reaction was produced on the ears of rabbits, sensitized by ox serum, and histologically examined.The reaction following the second re-injection repeated one month after the first re-injection was compared with the reaction following a single re-injection.Wounds were made on the ears of sensitized rabbits one month after the re-injection. On the other hand, antigen was intra-arterially or intracutan ously re-injected to the wounded ears of sensitized rabbits twelve hours after the wounding. The healing processes of these wound were histologically examined.The results of these experiments were summarized as follows.1) Intra-arterial injection of antigen are preferable to intracutaneous method as the method of re-injection, the reaction is intensified by arresting the local blood flow during a certain time immediately after the intra-arterial re-injection.2) The early exsudative reaction following the second re-injection is less marked than that following the single re-injection, but the massive small round cell infiltration is more marked after the repeated re-injection.3) In the wound healing process on the ears of rabbits, wounded one month after the re-injection, the proliferation of granulation and connective tissue is accelerated and the massive small round cell infiltration is intensified.4) Re-injection twelve hours after the wounding suppresses the development of granulation in an early stage of wound healing but thereafter accelerates the proliferation of connective tissue.5) Changes of the arterial intima and media are most commonly observable blo odvessel damages and these changes are intensified by repeated re-injections or wounding.6) From these results, it is thought that the function of the local connective tissue has been accentuated at least one month after the reinjection and blood vessels have been oversensitive during the same time.