In the electron microscopic observation on adenovirus type 12 infected cells, abundant virus particles can always be recognized in the nucleus, although in some rare instances virus particles are found in the cytoplasm. Therefore, it is difficult to consider the virus formation to take place aside from the nucleus and it seems that the nucleus is really the essential site of virus multiplication.The fact that there are two different arrangements of virus particles presents a problem. It appears that usually crystalline arrayed virus particles come into being, and then they take noncrystalline arrangement, but this sequence does not necessarilly take place. The crystalline arranged virus particles and noncrystalline arranged ones often appear simultaneously and independently of each other, At the early stage of infection, the electron dense masses are seen in the nucleus. These masses are the matrix of virus particles, because the arrangement of virus particles in crystalline or noncrystalline array are seen with these electron dense masses.
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