A new ursane and a new oleanane triterpene acids from the whole plant of Spermacoce latifolia

摘要

A phytochemical study on the whole plant of Spermacoce latifolia led to the isolation of a new ursane triterpene acid, 3 beta,6 beta,23-trihydroxy-urs-12,20(30)-dien-28-oic acid (1), and a new oleanane triterpene acid, 3 beta,6 beta,29-trihydroxy-olean-12-en-28-oic acid (2), together with seven known triterpenic acids (3-9). Their structures were established on the basis of detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI-MS and HR-ESI-MS techniques. All the compounds were isolated from S. latifolia for the first time. Compounds 3, 5, 6 and 9 were found to show in vitro growth inhibitory activity against three assayed human cancer cell lines MCF-7, NCI-H460 and HepG-2 with IC50 values from 9.53 to 80.20 mM. Compounds 1 and 3-9 were further revealed to show significantly in vitro alpha-glucosidase inhibitory activity with IC50 values from 0.009 to 0.422 mM, most of which were more potent than the reference compound acarbose (IC50 0.409 mM). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.