Biotransformation of Quinovic Acid Glycosides by Microbes: Direct Conversion of the Ursane to the Oleanane Triterpene Skeleton by Nocardia sp. NRRL 5646

摘要

Quinovic acid glycosides were microbially deglycosylated by a Nocardia sp. to their aglycon quinovic acid and its biogenetic counterpart, cincholic acid (3), via an unprecedented carbon skeleton rearrangement involving a methyl group migration. The structures of the metabolites were established by ESI-LC/MS and 2D-NMR techniques.