Stem cell therapy: an exercise in patience and prudence

摘要

In recent times, the epigenetic study of pluripotency based on cellular repro-gramming techniques led to the creation of induced pluripotent stem cells It has come to represent the forefront of a new wave of alternative therapeutic approaches in the field of stem cell therapy. Progress in drugs development has saved countless lives, but there arc numerous intractable diseases where curative treatment cannot be achieved through pharmacological intervention alone. Consequently, there has been an unfortunate rise: in incidences of organ failures, degenerative; disorders and, cancers, hences novel therapeutic interventions are required: Stem cells have unique self-renewal and multilineage differentiation capabilities that could be harnessed for therapeutic purposes. Akhouglra number of mature d feren tiated cells have been characterized in vitro, few have been demonstrated to function in a physiologically relevant context. Despite fervent levels of enthusiasm in the field, the reality is that other than, the employment of haematopoietic stem cells, many other therapies have yet to be thoroughly proven for their therapeutic benefit and safety in application This review shall focus on a discussion regarding the current status of stem cell therapy the issues surrounding it and its future prospects with a general background on the regulatory networks underlying pluripotency.