New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin

Riekes Manoela K.; Engelen Axel; Appeltans Bernard; Rombaut Patrick; Stulzer Hellen K.; Van den Mooter Guy

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New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin

机译：水溶性差的化合物的固定剂量组合的新观点：依泽替米贝和洛伐他汀的案例研究

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摘要

Aiming to improve the dissolution rate of ezetimibe (EZE) and lovastatin (LOV) in a fixed dose combination (FDC), co-amorphous systems and ternary solid dispersions were prepared by quench cooling and spray drying, respectively.

机译：为了提高依泽替米贝（EZE）和洛伐他汀（LOV）在固定剂量组合（FDC）中的溶解速率，分别通过骤冷和喷雾干燥制备了共非晶体系和三元固体分散体。

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《Pharmaceutical research》 |2016年第5期|共17页
作者
Riekes Manoela K.; Engelen Axel; Appeltans Bernard; Rombaut Patrick; Stulzer Hellen K.; Van den Mooter Guy;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
co-amorphous systems; ezetimibe; fixed dose combinations; lovastatin; ternary solid dispersions;

机译：共非晶体系;依泽替米贝;固定剂量组合;洛伐他汀;三元固体分散体;

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专利

1. New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin [J] . Riekes Manoela K., Engelen Axel, Appeltans Bernard, Pharmaceutical research . 2016,第5期

机译：水溶性差的化合物的固定剂量组合的新观点：依泽替米贝和洛伐他汀的案例研究
2. The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet. [J] . Menon R, Tolbert D, Cefali E Biopharmaceutics and Drug Disposition . 2007,第6期

机译：缓释烟酸和洛伐他汀固定剂量组合片剂与缓释烟酸片剂，洛伐他汀片剂以及缓释烟酸片剂和洛伐他汀片剂的组合的生物利用度比较。
3. Effect of fixed-dose combinations of ezetimibe plus rosuvastatin in patients with primary hypercholesterolemia: MRS-ROZE (Multicenter Randomized Study of ROsuvastatin and eZEtimibe) [J] . Kim Kyung-Jin, Kim Sang-Hyun, Yoon Young Won, Cardiovascular therapeutics . 2016,第5期

机译：依泽替米贝联合瑞舒伐他汀固定剂量联合治疗原发性高胆固醇血症的疗效：MRS-ROZE（瑞舒伐他汀和依泽替米贝的多中心随机研究）
4. Low-temperature synthesis of Zn2Si04:Mn phosphor with high purity and strong emission by a homogeneous precipitation method in combination with novel water-soluble silicon compounds [C] . Kohei Yoshizawa, Yoshihito Suzuki, Hideki Kato, International meeting on information display;International display manufacturing conference and Asia display;IMID/IDMC/Asia Display 2010 . 2010

机译：均相沉淀法结合新型水溶性硅化合物低温合成高纯度强发射态Zn2Si04：Mn荧光粉
5. Sample size determination for Emax model, equivalence/non-inferiority test and drug combination in fixed dose trials. [D] . Wang, Jie. 2008

机译：在固定剂量试验中确定Emax模型，等效性/非劣效性试验和药物组合的样本量。
6. Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Ezetimibe Compared with a Fixed-Dose Combination of Simvastatin and Ezetimibe in Brazilian Patients with Primary Hypercholesterolemia or Mixed Dyslipidemia: A Multicenter Randomized Trial [O] . Antonio Carlos Amedeo Vattimo, Francisco Antonio Helfestein Fonseca, Douglas Costa Morais, 2020

机译：罗苏伐他汀和欧塞蒂米贝的固定剂量组合的疗效和耐受性与司法素和欧洲血管血症患者的辛伐他汀和欧洲血管血症患者的固定剂量组合相比：多中心随机试验
7. Evaluation of Efficacy and Safety of Fixed Dose Lovastatin and NiacinER Combination in Asian Indian Dyslipidemic Patients: A Multicentric Study [O] . Sharma, Manoj, Sharma, Deepika R, Singh, Vikram, 2006

机译：固定剂量洛伐他汀和烟酸ER联合治疗亚洲印度血脂异常患者的疗效和安全性的多中心研究

New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin

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