The most reliable and characteristic finding of a fixed drug eruption is the recurrence of the lesion at the same site, which can be anywhere on the skin or mucosa. History taking is key to discerning the offending medication. Trimethoprim-sulfamethoxazole and acetaminophen are commonly implicated in causing fixed drug eruptions. The mainstay of treatment is to prevent recurrence of the eruption by avoiding the offending drug.
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