HYPOTHYRO1DISM IN NETHERTON SYNDROME

摘要

We read with special interest the article of Halverston et al (1), which described the occurrence of Cushing syndrome in a child with Netherton syndrome following cutaneous application of a low-potency corticosteroid. Netherton syndrome is characterized by loss of the physiologic function of the skin as a barrier against the external environment, which may lead to excessive loss of water through the skin and as a consequence, dehydration, hemoconcentration, hypernatremia, and hypothermia. In addition, this may cause an unpredictable absorption of any substance applied to the skin to levels consistent with systemic administration. We would like to describe another endocrine complication related to increased absorption of medication through the skin in a patient with Netherton syndrome.