Calcium and vitamin D for osteoprotection in children with new-onset nephrotic syndrome treated with steroids: A prospective, randomized, controlled, interventional study

摘要

Background: There are no robust guidelines on strategies to prevent the adverse skeletal effects of glucocorticoids in children. Objectives: To evaluate the role of prophylactic calcium and vitamin D on bone health in children with new-onset nephrotic syndrome (NS) treated with short-term (12 weeks), high-dose glucocorticoids. Methods: Prospective, randomized, controlled, single blind, interventional study conducted on 41 steroid-na?ve pre-pubertal children (29 boys, 12 girls). All children received prednisolone for 12 weeks (60 mg/m2/day daily for 6 weeks, followed by 40 mg/m2/day alternate days for 6 weeks). Recruited children were randomized into the intervention group (IG; vitamin D 1,000 IU/day and elemental calcium 500 mg/day) and the control group (CG). Bone mineral content (BMC) and bone mineral density (BMD) at the lumbar spine (L1-L4) were estimated at baseline and at 12 weeks. Mean percentage changes in BMC and BMD in IG and CG were compared. Results: Children in the IG showed an increase of 11.2 % in BMC versus the CG, who showed an 8.9 % fall (p0.0001). Net intervention-attributable difference in BMC was 20.1 %. BMD increased in both groups (IG 2.8 % vs CG 0.74 %), but the difference was not statistically significant (p=0.27). Conclusions: Short-term, high-dose glucocorticoid therapy decreases the BMC of the lumbar spine in steroid-na?ve children with NS. Vitamin D and calcium co-administration not only prevents this decline, but also enhances BMC of the lumbar spine.