METHOD OF PREDICTING PROGRESSING COURSE OF STEROID-RESISTANT NEPHROTIC SYNDROME IN CASE OF GLOMERULONEPHRITIS IN CHILDREN

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of medicine, in particular to nephrology. In order to predict progressing of steroid-resistant nephrotic syndrome in case of glomerulonephritis in children clinical-morphologic predictors of progressing and efficiency of the 1-st course of immunosuppressive therapy are estimated. As clinical-morphologic predictors of progressing determined are: "focal-segmental glomerulosclerosis, angiopathy of retinal vessels, increase of creatinine in blood in disease manifestation, stable increase of cholesterol level in blood 6.7 mmol/l, stable increase of fibrinogen in blood 4 g/l, disturbance of day rhythm of arterial pressure by "night-peackers" and "non-dippers" type, left ventricle hypertrophy in echocardiographic examination, increased size of kidneys in ultrasonic examination". If more than four clinical-morphologic predictors are detected and/or there is no effect from the 1-st course of immunosuppressive therapy, progressing of steroid-resistant nephrotic syndrome in case of glomerulonephritis in children is predicted.;EFFECT: method makes it possible to predict progressing course of steroid-resistant nephrotic syndrome in case of glomerulonephritis in children on the basis of early detection of clinical and morphologic predictors.;2 ex, 4 tbl