Multicomponent synthesis of highly substituted imidazolines via a silicon mediated 1,3-dipolar cycloaddition

摘要

A diastereoselective multicomponent synthesis of highly functionalized imidazolines is reported. A silicon mediated 1, 3 di-polar cycloaddition of the in situ generated munchnone with an imine resulted in the formation of highly substituted imidazolines. The imidazolines contain a four-point diversity and two stereocenters and the cycloaddition reaction is applicable to aryl, alkyl, acyl, and heterocyclic substitutions. [References: 37]