Facile Synthesis of Bicyclo Orthoesters and Bicyclo Amide Acetals Using alpha,alpha-Difluoroalkylamines

摘要

Abstract: Bicyclo orthoesters and amide acetals were prepared from the corresponding triols or diethanolamines using alpha,alpha-difluo-roalkylamines. The reaction proceeded under milder conditions than conventional methods. 4-teri-Butyl-l-(4-ethynylphenyl)tri-oxabicyclo[2.2.2]octane, a new class of insecticide, was prepared from a triol in three steps using a difluoroalkylamine.