Enantioselective Synthesis of Trifluoromethylated Tertiary Thioethers through Organocatalytic Sulfa-Michael Addition of Thiols to beta-Trifluoromethyl beta,beta-Disubstituted Enones

摘要

An organocatalytic asymmetric sulfa-Michael addition of thiols to -trifluoromethyl ,-disubstituted (E)-enones in the presence of 10 mol% of a cinchona alkaloid-derived thiourea catalyst provides direct and simple access to chiral trifluoromethyl tertiary thioethers in high yields and up to 76% ee.