The Reaction of 2-(Acylamino) benzonitriles with Primary Aromatic Amines: A Convenient Synthesis of 2-Substituted 4-(Arylamino) quinazolines

摘要

2-Substituted 4-(arylamino) quinazolines were prepared from 2-(acylamino) benzonitriles and primary arylamines by refluxing in either ethanol using trifluoroacetic acid as a catalyst or acetic acid. The 2-aminobenzonitrile was acylated by reaction with anhydrides, isocyanates, or ethyl chloroformate at room temperature.