Multiple compulsive behaviors in multiple system atrophy: the importance of predisposition to addiction.

摘要

Impulse control disorders (ICDs) and dopamine dysregulation syndrome (DDS) are usually described as non-motor complications of dopaminergic medications in a minority of vulnerable subjects with Parkinson's disease (PD), but they may also occur in non-neurodegenerative disorders (i.e. RLS, prolactinoma) [1 ]. Predisposing factors include (a) greater impulsive and novelty-seeking personality traits and (b) personal/family history of substance abuse [1]. The association between substance-addiction and these addictive syndromes (ICDs and/or DDS) is reported in one third of medicated PD patients [1] and is further strengthened by the reclassification of pathological gambling among 'addictive disorders' in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders. Questionnaires measuring personality traits according to the big-five model proved to be highly reliable in predicting the manner in which individuals actually behave in real situations [2].