Facile Synthesis of a Novel Taxoid Closely Related to Bioactive Taxuspine D. Regio- and Stereo-Selective Hydration of Taxinine, a Naturally Occurring Taxane Diterpenoid

摘要

Treatment of taxinine, which is a taxane diterpenoid readily available from needles of the Japanese yew Taxus cuspidata, with a large excess amount of sodium borohydride in slightly hydrous N,N-dimethylformamide at ambient temperature resulted in regio- and stereo-selective hydration at the C_(11), C_(12)-double bond to give an isomeric taxuspine D derivative.