An efficient and facile synthesis of 2-chloro-3-formyl quinolines from acetanilides in micellar media by Vilsmeier-Haack cyclisation

摘要

Acetanilides efficiently undergo Vilsmeier Haack cyclisation in micellar media to afford 2-chloro-3-formyl quinoline derivatives in good yields. This procedure works efficiently in CTAB (cetyl trimethyl ammonium bromide), SDS (sodium dodecyl sulphate) and TX (Triton-X-100) media under reflux conditions particularly from deactivated acetanilides in good yields. [References: 42]